To Overcome failure to Publish nEgative fiNdings


1. OPEN Publications

Meerpohl JJ, Schell LK, Bassler D, Gallus S, Kleijnen J, Kulig M, La Vecchia C, Marušić A, Ravaud P, Reis A, Schmucker C, Strech D, Urrútia G, Wager E, Antes G; OPEN project consortium. Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN (Overcome failure to Publish nEgative fiNdings) project based on an international consensus meeting. BMJ Open. 2015 May 5;5(5):e006666. doi: 10.1136/bmjopen-2014-006666. PMID: 25943371

Work package 1

Mueller KF, Meerpohl JJ, Briel M, Antes G, von Elm E, Lang B, Motschall E, Schwarzer G, Bassler D. Methods for detecting, quantifying, and adjusting for dissemination bias in meta-analysis are described. J Clin Epidemiol. 2016 Aug 5. pii: S0895-4356(16)30301-8. doi: 10.1016/j.jclinepi.2016.04.015. PMID: 27502970

Bassler D, Mueller KF, Briel M, Kleijnen J, Marusic A, Wager E, Antes G, von Elm E, Altman DG, Meerpohl JJ; OPEN Consortium. Bias in dissemination of clinical research findings: structured OPEN framework of what, who and why, based on literature review and expert consensus. BMJ Open. 2016 Jan 21;6(1):e010024. doi: 10.1136/bmjopen-2015-010024. PMID: 26801469

Mueller KF, Briel M, Strech D, Meerpohl JJ, Lang B, Motschall E, Gloy V, Lamontagne F, Bassler D. Dissemination bias in systematic reviews of animal research: a systematic review. PLoS One. 2014 Dec 26;9(12):e116016. doi: 10.1371/journal.pone.0116016. eCollection 2014. PMID: 25541734

Schmucker C, Schell LK, Portalupi S, Oeller P, Cabrera L, Bassler D, Schwarzer G, Scherer RW, Antes G, von Elm E, Meerpohl JJ; OPEN consortium. Extent of non-publication in cohorts of studies approved by research ethics committees or included in trial registries. PLoS One. 2014 Dec 23;9(12):e114023. doi: 10.1371/journal.pone.0114023. eCollection 2014. PMID: 25536072

Briel M, Mueller KF, Meerpohl JJ, von Elm E, Lang B, Motschall E, Gloy V, Lamontagne F, Schwarzer G, Bassler D. Publication bias in animal research: a systematic review protocol. Syst Rev. 2013 Apr 27; 2(1):23.

Mueller KF, Meerpohl JJ, Briel M, Antes G, von Elm E, Lang B, Gloy V, Motschall E, Schwarzer G, Bassler D. Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods. Syst Rev. 2013 Jul 25;2:60. doi: 10.1186/2046-4053-2-60.

Portalupi S, von Elm E, Schmucker C, Lang B, Motschall E, Schwarzer G, Gross IT, Scherer RW, Bassler D, Meerpohl JJ. Protocol for a systematic review on the extent of non-publication of research studies and associated study characteristics. Syst Rev. 2013 Jan 9; 2(1):2. doi: 10.1186/2046-4053-2-2.

Schmucker C, Bluemle A, Briel M, Portalupi S, Lang B, Motschall E, Schwarzer G, Bassler D, Mueller KF, von Elm E, Meerpohl JJ.
A protocol for a systematic review on the impact of unpublished studies and studies published in the gray literature in meta-analyses. Syst Rev. 2013 May 2; 2(1):24. doi:10.1186/2046-4053-2-24

Work package 4

Strech D, Littmann J. The contribution and attitudes of research ethics committees to complete registration and non-selective reporting of clinical trials: A European survey. Research Ethics. I-14 2016. doi: 10.1177/1747016115626497

Work package 6

Malički M, Marušić A, on behalf of the OPEN (to Overcome failure to Publish nEgative fiNdings) Consortium. Is there a solution to publication bias? Researchers call for changes in dissemination of clinical research results. J Clin Epidemiol. 2014 Oct;67(10):1103-10. doi: 10.1016/j.jclinepi.2014.06.002. Epub 2014 Jul 14. PMID: 25034197.

Work package 7

Viergever RF, Karam G, Reis A, Ghersi D. The quality of registration of clinical trials: still a problem. PLoS One. 2014 Jan 10;9(1):e84727. doi: 10.1371/journal.pone.0084727. eCollection 2014. PMID: 24427293

Work package 8

Wager E, Williams P on behalf of the OPEN Project (Overcome failure to Publish nEgative fiNdings) Consortium. “Hardly worth the effort”? Medical journals’ policies and their editors’ and publishers’ views on trial registration and publication bias: quantitative and qualitative study. BMJ 2013; 347 doi: (Published 6 September 2013) BMJ 2013;347:f5248

Work package 10

Panteli D, Nolting A, Eckhardt H, Kulig M, Busse R. Published and unpublished evidence in coverage decision-making for pharmaceuticals in Europe: existing approaches and way forward. Health Res Policy Syst. 2016 Jan 26;14(1):6. doi: 10.1186/s12961-016-0080-9. PMID: 26813738

Panteli D, Eckhardt H, Nolting A, Busse R, Kulig M. From market access to patient access: overview of evidence-based approaches for the reimbursement and pricing of pharmaceuticals in 36 European countries.Health Res Policy Syst. 2015 Sep 25;13:39. doi: 10.1186/s12961-015-0028-5. PMID: 26407728

Work package 11:

Estellat C, Ravaud P. Lack of Head-to-head Trials and Fair Control Arms. Randomized Controlled Trials of Biologic Treatment for Rheumatoid Arthritis. Arch Intern Med. 2012;172(3):237-244. PMID:22332155

Trinquart L, Abbé A, Ravaud P. Impact of Reporting Bias in Network Meta-Analysis of Antidepressant Placebo-Controlled Trials. PLoS ONE. 2012  7(4): e35219. doi:10.1371/journal.pone.0035219

2. General publications


Littmann J, Antes G, Strech D, Meerpohl JJ. To overcome failure to publish negative findings: The OPEN project. Maturitas. 2013 Jul 18. doi:pii: S0378-5122(13)00198-9. 10.1016/j.maturitas.2013.06.014.


Strech D, Littmann J. Commentary: Lack of proportionality. Seven specifications of public interest that override post-approval commercial interests on limited access to clinical data. Trials 2012, 13:100. doi:10.1186/1745-6215-13-100


Kunath F, Grobe HR, Keck B, et al. Do urology journals enforce trial registration? A cross-sectional study of published trials. BMJ Open 2011;1:e000430. doi:10.1136/bmjopen-2011-000430

Huić M, Marušić M, Marušić A. Completeness and Changes in Registered Data and Reporting Bias of Randomized Controlled Trials in ICMJE Journals after Trial Registration Policy. PLoS ONE. 2011 6(9): e25258. doi:10.1371/journal.pone.0025258

Strech D. Normative arguments and new solutions for the unbiased registration and publication of clinical trials. J Clin Epidemiol. 2011 Oct 18. PMID: 22014887. doi: 10.1016/j.jclinepi.2011.07.002

Page last updated: Thu 13th Oct 2016 10:52:14 CEST


The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7 – HEALTH.2011.4.1-2) under grant agreement n° 285453.